Monday, January 18, 2010

spend a moment to t.h.i.n.k

caution : this post might contain nonsense to some people

of all this time
we had always known that human *especially girls* are very sensitive and prone to be hurt emotionally

little did we know
organs are sensitive too
*in the sense "pandai merajuk"*

this post will illustrate two phenomena in which the writer *me obviously* observe how organs "merajuk"

phenomena 1
*2nd endocrine PBL - rain & drain*

in this particular pbl, we learned almost everything we need to know on one of the most common medical conditions,
Diabetes Mellitus

*note the usage of the word "almost"..this indicates the feeling of the writer who thought that there are still a lot of things to know on dm*

in the pathogenesis *pathogenesis = the process on how the disease manifest itself* of type 2 dm, there are two mechanisms that happens

mechanism number one
insulin resistance

this one is very closely-related to obesity
in this mechanism, it is said that our peripheral tissues *namely the fat cells and the muscle cells* had become resistant towards the effect of insulin
so this leads to the disability of those tissues mentioned above to take up glucose which is important for their energy source
eventually, the glucose we consumed during our meal *rice,potato,etc* remains and accumulates in the blood leading to hyperglycaemia *hyper = a lot, glyc = glucose, aemia = blood*

but unfortunately, this mechanism has nothing to do with the purpose of writing this post
what's intriguing to the writer is the second mechanism

mechanism number two
B-cell dysfunction

secondary to the first mechanism mentioned above
as an adaptive process, the B-cells of the islet of Langerhans of the pancreas *these cells are specialized cells which are found in the pancreas and function to synthesise and secrete insulin* will try to overcome the resistance and secrete more and more insulin so that the level of glucose in our body can be regulated
the interesting part is that, after quite some time *text book mentions few years* these B-cells will be exhausted and stop producing insulin
this eventually leads to overt diabetes

in this second mechanism, the writer is very much fascinated on how the B-cells surrender most probably due to exhaustion and stop functioning
just like all of us, even cells have feeling of tiredness and decided to let go after realising for some time that whatever that they are doing doesnt make so much different
it is easy for us to watch people strive their hardest and say "keep going" and "never give up"
but, do we exactly realise how much pain do people have to endure in order to keep going and never give up?

phenomena 2
*pharmacology lecture on steroids*

in this lecture which had just ended few hours ago, there was one term that made the writer stops and thinks
Adrenal Suppression

this is one of the toxicities of glucocorticoids *ie : prednisolone, dexamethasone* which happens in patients with prolonged administration of them
this happens when our adrenal cortex which normally functions to secrete these endogenous glucocorticoids decided to stop doing so due to the presence of exogenous ones
what happen is that, the adrenal tissue sort of stopping itself from doing its job because somebody else already did which refers to the doctors who are responsible in administering the drugs
i dont call it as cheating, but it does look like one, doesnt it?

just like us also, when there are somebody else doing our job
we tend to let go of the responsibility
*the writer does this too sometimes and she believes others do as well*

overall conclusion

God makes us the most exquisite creation exist on this Earth. we *particularly the medical students* learn on everything about our body. the anatomy, physiology, biochemistry, pathology and all other aspects of human being and life. but do we ever realise how closely our body and our personality related? things that the writer mentioned above were only two examples of all the other miraculous creations of God that was actually present in our daily life as in our daily practices. there are still more to be discovered.

humans are beautiful, arent they?

till then



Sarinah T said...

like the use of word 'merajuk' particularly to the tissues =)

p/s: noticed the change of mode of writing. nadhira refers to herself as 'the writer'... :)

MyOwNwOrLd said...

great way of thinking~~

never even think such a way bout steroids like u
(obviously because im so busy eating keropok during d lecture)


nadhira khairudin said...

sarinah : saje2 tukar mode of writing...bosanla kalau monotonous je~~anyway,sape ckp cells xbley merajuk

p/s : sarinah,bkk nota adrenal diseases,mamat dgn handcuff kt lengan tu senyum kt awk...hahahaha

ira : huhu..sye mmg begini...ske pkir pelik2..hahaha

Sarinah T said...

hahaha...nsib baik gmbr handcuff kt lengan die je (i'm fine with it)

p/s: nadhira, bkk nota steroid, and the Cushingoid guy misses you, he never stop smiling...
(oh no, can't stop laughing right now):P

nadhira khairudin said...

sarinah : we can keep on having this conversation like forever..tape2...mamat tu rindu btul nk senyum kt awk..esk sye bwk die jmpe awk oke!!

p/s : sye bce nota steroids skip part tu sbb xbley stop gelak!!

mrym said...

great post this is!
love the analogy,it's sooo very true.

nadhira khairudin said...

maryam : thanks yam!! =D

kamarudin abdullah said...

informative! =)

nadhira khairudin said...

thanks qama~~
just expressing my feeling and thoughts on things learned!! =D